|
rs12608932
|
|
C |
0.880 |
GeneticVariation |
GWASDB |
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
|
24234648 |
2014 |
|
rs12608932
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
|
20801717 |
2010 |
|
rs12608932
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs12608932
|
|
C |
0.880 |
GeneticVariation |
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASDB |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
|
rs3849942
|
|
A |
0.870 |
GeneticVariation |
GWASDB |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs3849942
|
|
A |
0.870 |
GeneticVariation |
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASDB |
Genome-wide association testing was performed first using all samples, and then restricting the analysis to samples not carrying the mutation. rs3849942 and rs903603 were strongly associated with ALS when all samples were included (rs3849942, p = [3 × 2] × 10(-6), rank 7/442,057; rs903603, p = [7 × 6] × 10(-8), rank 2/442,057).
|
23587638 |
2013 |
|
rs1541160
|
|
C |
0.830 |
GeneticVariation |
GWASDB |
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
|
19451621 |
2009 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
|
20801718 |
2010 |
|
rs10260404
|
|
C |
0.820 |
GeneticVariation |
GWASDB |
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
|
18084291 |
2008 |
|
rs13048019
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
|
20801718 |
2010 |
|
rs3113494
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Although no SNPs reached genome-wide significance in the discovery phase for either phenotype, three SNPs were statistically significant in the replication analysis of ALS outcome: rs6080539 (177 kb from PCSK2), rs7000234 (4 kb from ZNF704), and rs3113494 (13 kb from LOC100506746).
|
22470424 |
2012 |
|
rs4363506
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data.
|
17362836 |
2007 |
|
rs6703183
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, Pcombined = 2.92 × 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, Pcombined = 2.35 × 10(-9), OR = 1.52).
|
23624525 |
2013 |
|
rs7477
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
rs8141797
|
|
G |
0.810 |
GeneticVariation |
GWASDB |
We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, Pcombined = 2.92 × 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, Pcombined = 2.35 × 10(-9), OR = 1.52).
|
23624525 |
2013 |
|
rs10122902
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
|
20801717 |
2010 |
|
rs10438933
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
|
19451621 |
2009 |
|
rs11082762
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
|
22959728 |
2013 |
|
rs1971791
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
|
22959728 |
2013 |
|
rs2006933
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
|
22959728 |
2013 |